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Binding of tobramycin leads to conformational changes in yeast tRNA(Asp) and inhibition of aminoacylation

Aminoglycosides inhibit translation in bacteria by binding to the A site in the ribosome. Here, it is shown that, in yeast, aminoglycosides can also interfere with other processes of translation in vitro. Steady-state aminoacylation kinetics of unmodified yeast tRNA(Asp) transcript indicate that the...

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Udgivet i:EMBO J
Principais autores: Walter, Frank, Pütz, Joern, Giegé, Richard, Westhof, Eric
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2002
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125865/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11847123/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.4.760
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