Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death

Cain/cabin1 is an endogenous inhibitor of calcineurin (Cn), a calcium-dependent serine/threonine phosphatase involved in various cellular functions including apoptosis. We show here that during apoptosis cain/cabin1 is cleaved by calpain at the carboxyl terminus to generate a cleavage product with a...

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Bibliographic Details
Main Authors: Kim, Min-Jung, Jo, Dong-Gyu, Hong, Gil-Sun, Kim, Byung Ju, Lai, Michael, Cho, Dong-Hyung, Kim, Ki-Woo, Bandyopadhyay, Arun, Hong, Yeon-Mi, Kim, Do Han, Cho, Chunghee, Liu, Jun O., Snyder, Solomon H., Jung, Yong-Keun
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC125047/
https://ncbi.nlm.nih.gov/pubmed/12114545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.152336999
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