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FK506 reduces calpain-regulated calcineurin activity in both the cytoplasm and the nucleus
Excessive immune responses induced by ischemia-reperfusion injury (IRI) are known to lead to necrotic and apoptotic cell death, and calcineurin plays a major role in this process. Calcineurin dephosphorylates the nuclear factor of activated T-cells (NFAT), permitting its translocation into the nucle...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Korean Association of Anatomists
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4076426/ https://ncbi.nlm.nih.gov/pubmed/24987545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5115/acb.2014.47.2.91 |
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