FK506 reduces calpain-regulated calcineurin activity in both the cytoplasm and the nucleus

Excessive immune responses induced by ischemia-reperfusion injury (IRI) are known to lead to necrotic and apoptotic cell death, and calcineurin plays a major role in this process. Calcineurin dephosphorylates the nuclear factor of activated T-cells (NFAT), permitting its translocation into the nucle...

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Hlavní autoři: Lee, Sun Hee, Choi, Jungil, Kim, Hwajin, Lee, Dong Hoon, Roh, Gu Seob, Kim, Hyun Joon, Kang, Sang Soo, Choi, Wan Sung, Cho, Gyeong Jae
Médium: Artigo
Jazyk:Inglês
Vydáno: Korean Association of Anatomists 2014
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4076426/
https://ncbi.nlm.nih.gov/pubmed/24987545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5115/acb.2014.47.2.91
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