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Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death
Cain/cabin1 is an endogenous inhibitor of calcineurin (Cn), a calcium-dependent serine/threonine phosphatase involved in various cellular functions including apoptosis. We show here that during apoptosis cain/cabin1 is cleaved by calpain at the carboxyl terminus to generate a cleavage product with a...
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| 主要な著者: | , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The National Academy of Sciences
2002
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125047/ https://ncbi.nlm.nih.gov/pubmed/12114545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.152336999 |
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