Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases

Acetaminophen has antipyretic and analgesic properties yet differs from the nonsteroidal antiinflammatory drugs and inhibitors of prostaglandin H synthase (PGHS)-2 by exhibiting little effect on platelets or inflammation. We find parallel selectivity at a cellular level; acetaminophen inhibits PGHS...

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Hlavní autoři: Boutaud, Olivier, Aronoff, David M., Richardson, Jacob H., Marnett, Lawrence J., Oates, John A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2002
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC124540/
https://ncbi.nlm.nih.gov/pubmed/12011469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.102588199
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