Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases

Acetaminophen has antipyretic and analgesic properties yet differs from the nonsteroidal antiinflammatory drugs and inhibitors of prostaglandin H synthase (PGHS)-2 by exhibiting little effect on platelets or inflammation. We find parallel selectivity at a cellular level; acetaminophen inhibits PGHS...

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Detaylı Bibliyografya
Asıl Yazarlar: Boutaud, Olivier, Aronoff, David M., Richardson, Jacob H., Marnett, Lawrence J., Oates, John A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 2002
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC124540/
https://ncbi.nlm.nih.gov/pubmed/12011469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.102588199
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