Nitroarachidonic Acid, a Novel Peroxidase Inhibitor of Prostaglandin Endoperoxide H Synthases 1 and 2

Prostaglandin endoperoxide H synthase (PGHS) catalyzes the oxidation of arachidonate to prostaglandin H(2). We have previously synthesized and chemically characterized nitroarachidonic acid (AANO(2)), a novel anti-inflammatory signaling mediator. Herein, the interaction of AANO(2) with PGHS was anal...

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Bibliographic Details
Main Authors: Trostchansky, Andrés, Bonilla, Lucía, Thomas, Christopher P., O’Donnell, Valerie B., Marnett, Lawrence J., Radi, Rafael, Rubbo, Homero
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3075636/
https://ncbi.nlm.nih.gov/pubmed/21266582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.154518
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