A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP

Presenilins mediate an unusual intramembranous proteolytic activity known as γ-secretase, two substrates of which are the Notch receptor (Notch) and the β-amyloid precursor protein (APP). γ-Secretase-mediated cleavage of APP, like that of Notch, yields an intracellular fragment [APP intracellular do...

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Detalles Bibliográficos
Main Authors: Leissring, Malcolm A., Murphy, M. Paul, Mead, Tonya R., Akbari, Yama, Sugarman, Michael C., Jannatipour, Mehrdad, Anliker, Brigitte, Müller, Ulrike, Saftig, Paul, De Strooper, Bart, Wolfe, Michael S., Golde, Todd E., LaFerla, Frank M.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC123710/
https://ncbi.nlm.nih.gov/pubmed/11917117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.072033799
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