A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP

Presenilins mediate an unusual intramembranous proteolytic activity known as γ-secretase, two substrates of which are the Notch receptor (Notch) and the β-amyloid precursor protein (APP). γ-Secretase-mediated cleavage of APP, like that of Notch, yields an intracellular fragment [APP intracellular do...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Leissring, Malcolm A., Murphy, M. Paul, Mead, Tonya R., Akbari, Yama, Sugarman, Michael C., Jannatipour, Mehrdad, Anliker, Brigitte, Müller, Ulrike, Saftig, Paul, De Strooper, Bart, Wolfe, Michael S., Golde, Todd E., LaFerla, Frank M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The National Academy of Sciences 2002
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC123710/
https://ncbi.nlm.nih.gov/pubmed/11917117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.072033799
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