A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP

Presenilins mediate an unusual intramembranous proteolytic activity known as γ-secretase, two substrates of which are the Notch receptor (Notch) and the β-amyloid precursor protein (APP). γ-Secretase-mediated cleavage of APP, like that of Notch, yields an intracellular fragment [APP intracellular do...

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Bibliographische Detailangaben
Hauptverfasser: Leissring, Malcolm A., Murphy, M. Paul, Mead, Tonya R., Akbari, Yama, Sugarman, Michael C., Jannatipour, Mehrdad, Anliker, Brigitte, Müller, Ulrike, Saftig, Paul, De Strooper, Bart, Wolfe, Michael S., Golde, Todd E., LaFerla, Frank M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2002
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC123710/
https://ncbi.nlm.nih.gov/pubmed/11917117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.072033799
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