A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP

Presenilins mediate an unusual intramembranous proteolytic activity known as γ-secretase, two substrates of which are the Notch receptor (Notch) and the β-amyloid precursor protein (APP). γ-Secretase-mediated cleavage of APP, like that of Notch, yields an intracellular fragment [APP intracellular do...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Leissring, Malcolm A., Murphy, M. Paul, Mead, Tonya R., Akbari, Yama, Sugarman, Michael C., Jannatipour, Mehrdad, Anliker, Brigitte, Müller, Ulrike, Saftig, Paul, De Strooper, Bart, Wolfe, Michael S., Golde, Todd E., LaFerla, Frank M.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The National Academy of Sciences 2002
Θέματα:
Biological Sciences
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC123710/
https://ncbi.nlm.nih.gov/pubmed/11917117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.072033799
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