A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP

Presenilins mediate an unusual intramembranous proteolytic activity known as γ-secretase, two substrates of which are the Notch receptor (Notch) and the β-amyloid precursor protein (APP). γ-Secretase-mediated cleavage of APP, like that of Notch, yields an intracellular fragment [APP intracellular do...

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Detalhes bibliográficos
Main Authors: Leissring, Malcolm A., Murphy, M. Paul, Mead, Tonya R., Akbari, Yama, Sugarman, Michael C., Jannatipour, Mehrdad, Anliker, Brigitte, Müller, Ulrike, Saftig, Paul, De Strooper, Bart, Wolfe, Michael S., Golde, Todd E., LaFerla, Frank M.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC123710/
https://ncbi.nlm.nih.gov/pubmed/11917117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.072033799
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