Capacitative Calcium Entry Deficits and Elevated Luminal Calcium Content in Mutant Presenilin-1 Knockin Mice

Dysregulation of calcium signaling has been causally implicated in brain aging and Alzheimer's disease. Mutations in the presenilin genes (PS1, PS2), the leading cause of autosomal dominant familial Alzheimer's disease (FAD), cause highly specific alterations in intracellular calcium signa...

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Detalhes bibliográficos
Main Authors: Leissring, Malcolm A., Akbari, Yama, Fanger, Christopher M., Cahalan, Michael D., Mattson, Mark P., LaFerla, Frank M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2000
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174559/
https://ncbi.nlm.nih.gov/pubmed/10811821
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