SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production

In addition to disrupting the regulated intramembraneous proteolysis of key substrates, mutations in the presenilins also alter calcium homeostasis, but the mechanism linking presenilins and calcium regulation is unresolved. At rest, cytosolic Ca(2+) is maintained at low levels by pumping Ca(2+) int...

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Bibliografiska uppgifter
Huvudupphovsmän: Green, Kim N., Demuro, Angelo, Akbari, Yama, Hitt, Brian D., Smith, Ian F., Parker, Ian, LaFerla, Frank M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2008
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442205/
https://ncbi.nlm.nih.gov/pubmed/18591429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200706171
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