Calsenilin reverses presenilin-mediated enhancement of calcium signaling

Most cases of autosomal-dominant familial Alzheimer's disease are linked to mutations in the presenilin genes (PS1 and PS2). In addition to modulating β-amyloid production, presenilin mutations also produce highly specific and selective alterations in intracellular calcium signaling. Although t...

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Hauptverfasser: Leissring, Malcolm A., Yamasaki, Tritia R., Wasco, Wilma, Buxbaum, Joseph D., Parker, Ian, LaFerla, Frank M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2000
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC26992/
https://ncbi.nlm.nih.gov/pubmed/10900016
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