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Gene expression profiling in conjunction with physiological rescues of IKKα null cells with Wt. or mutant IKKα reveals distinct classes of IKKα/NF-κB dependent genes
Cellular responses to stress-like stimuli require the IKK signalsome (IKKα, IKKβ and NEMO/IKKγ) to activate NF-κB dependent genes. IKKβ and NEMO/IKKγ are required to release NF-κB p65/p50 heterodimers from IκBα, resulting in their nuclear migration and sequence specific DNA binding; but IKKα was fou...
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| Asıl Yazarlar: | , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2005
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1226413/ https://ncbi.nlm.nih.gov/pubmed/15695520 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M414401200 |
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