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Gene expression profiling in conjunction with physiological rescues of IKKα null cells with Wt. or mutant IKKα reveals distinct classes of IKKα/NF-κB dependent genes

Cellular responses to stress-like stimuli require the IKK signalsome (IKKα, IKKβ and NEMO/IKKγ) to activate NF-κB dependent genes. IKKβ and NEMO/IKKγ are required to release NF-κB p65/p50 heterodimers from IκBα, resulting in their nuclear migration and sequence specific DNA binding; but IKKα was fou...

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Detalhes bibliográficos
Main Authors:	MASSA, Paul E., LI, Xiang, HANIDU, Adedayo, SIAMAS, John, PARIALI, Milena, PAREJA, Jessica, SAVITT, Anne G., Catron, Katrina M., LI, Jun, MARCU, Kenneth B.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	2005
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.gov/pmc/articles/PMC1226413/ https://ncbi.nlm.nih.gov/pubmed/15695520 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M414401200
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Gene expression profiling in conjunction with physiological rescues of IKKα null cells with Wt. or mutant IKKα reveals distinct classes of IKKα/NF-κB dependent genes

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