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Functional Isoforms of IκB Kinase α (IKKα) Lacking Leucine Zipper and Helix-Loop-Helix Domains Reveal that IKKα and IKKβ Have Different Activation Requirements

The activity of the NF-κB family of transcription factors is regulated principally by phosphorylation and subsequent degradation of their inhibitory IκB subunits. Site-specific serine phosphorylation of IκBs by two IκB kinases (IKKα [also known as CHUK] and IKKβ) targets them for proteolysis. IKKα a...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: McKenzie, Fergus R., Connelly, Margery A., Balzarano, Darlene, Müller, Jurgen R., Geleziunas, Romas, Marcu, Kenneth B.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2000
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC85479/
https://ncbi.nlm.nih.gov/pubmed/10733566
Tagiau: Ychwanegu Tag
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