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Functional Isoforms of IκB Kinase α (IKKα) Lacking Leucine Zipper and Helix-Loop-Helix Domains Reveal that IKKα and IKKβ Have Different Activation Requirements

The activity of the NF-κB family of transcription factors is regulated principally by phosphorylation and subsequent degradation of their inhibitory IκB subunits. Site-specific serine phosphorylation of IκBs by two IκB kinases (IKKα [also known as CHUK] and IKKβ) targets them for proteolysis. IKKα a...

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Udgivet i:Mol Cell Biol
Principais autores: McKenzie, Fergus R., Connelly, Margery A., Balzarano, Darlene, Müller, Jurgen R., Geleziunas, Romas, Marcu, Kenneth B.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2000
Fag:
Gene Expression
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85479/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10733566/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.8.2635-2649.2000
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