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Non-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor

Non-homologous end joining (NHEJ) and homologous recombination (HR) are pathways that repair DNA double-strand breaks (DSBs). In Saccharomyces cerevisiae, the repair of these breaks is influenced by histone acetylation. Therefore, we tested mammalian cells deleted for NHEJ (Ku80 or DNA Ligase IV) or...

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Bibliografiske detaljer
Main Authors: Yaneva, Mariana, Li, Han, Marple, Teresa, Hasty, Paul
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1226312/
https://ncbi.nlm.nih.gov/pubmed/16177181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki821
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