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Inference of functional regions in proteins by quantification of evolutionary constraints

Likelihood estimates of local rates of evolution within proteins reveal that selective constraints on structure and function are quantitatively stable over billions of years of divergence. The stability of constraints produces an intramolecular clock that gives each protein a characteristic pattern...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
I whakaputaina i:Proc Natl Acad Sci U S A
Ngā kaituhi matua: Simon, Alexander L., Stone, Eric A., Sidow, Arend
Hōputu: Artigo
Reo:Inglês
I whakaputaina: National Academy of Sciences 2002
Ngā marau:
Urunga tuihono:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122447/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11880638/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.042692299
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