Inference of functional regions in proteins by quantification of evolutionary constraints

Likelihood estimates of local rates of evolution within proteins reveal that selective constraints on structure and function are quantitatively stable over billions of years of divergence. The stability of constraints produces an intramolecular clock that gives each protein a characteristic pattern...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Simon, Alexander L., Stone, Eric A., Sidow, Arend
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 2002
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122447/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11880638/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.042692299
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