Inference of functional regions in proteins by quantification of evolutionary constraints
Likelihood estimates of local rates of evolution within proteins reveal that selective constraints on structure and function are quantitatively stable over billions of years of divergence. The stability of constraints produces an intramolecular clock that gives each protein a characteristic pattern...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2002
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122447/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11880638/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.042692299 |
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