Inference of functional regions in proteins by quantification of evolutionary constraints

Likelihood estimates of local rates of evolution within proteins reveal that selective constraints on structure and function are quantitatively stable over billions of years of divergence. The stability of constraints produces an intramolecular clock that gives each protein a characteristic pattern...

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Cyhoeddwyd yn:	Proc Natl Acad Sci U S A
Prif Awduron:	Simon, Alexander L., Stone, Eric A., Sidow, Arend
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	National Academy of Sciences 2002
Pynciau:	Biological Sciences
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122447/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11880638/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.042692299
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