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Noncoding regulatory sequences of Ciona exhibit strong correspondence between evolutionary constraint and functional importance

We show that sequence comparisons at different levels of resolution can efficiently guide functional analyses of regulatory regions in the ascidians Ciona savignyi and Ciona intestinalis. Sequence alignments of several tissue-specific genes guided discovery of minimal regulatory regions that are act...

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Sábháilte in:
Sonraí bibleagrafaíochta
Foilsithe in:Genome Res
Príomhchruthaitheoirí: Johnson, David S., Davidson, Brad, Brown, Christopher D., Smith, William C., Sidow, Arend
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Cold Spring Harbor Laboratory Press 2004
Ábhair:
Rochtain ar líne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC534669/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15545496/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gr.2964504
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