Noncoding regulatory sequences of Ciona exhibit strong correspondence between evolutionary constraint and functional importance

We show that sequence comparisons at different levels of resolution can efficiently guide functional analyses of regulatory regions in the ascidians Ciona savignyi and Ciona intestinalis. Sequence alignments of several tissue-specific genes guided discovery of minimal regulatory regions that are act...

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Detalhes bibliográficos

Publicado no:	Genome Res
Principais autores:	Johnson, David S., Davidson, Brad, Brown, Christopher D., Smith, William C., Sidow, Arend
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Cold Spring Harbor Laboratory Press 2004
Assuntos:	Letters
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC534669/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15545496/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gr.2964504
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