Noncoding regulatory sequences of Ciona exhibit strong correspondence between evolutionary constraint and functional importance

We show that sequence comparisons at different levels of resolution can efficiently guide functional analyses of regulatory regions in the ascidians Ciona savignyi and Ciona intestinalis. Sequence alignments of several tissue-specific genes guided discovery of minimal regulatory regions that are act...

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Bibliografski detalji

Izdano u:	Genome Res
Glavni autori:	Johnson, David S., Davidson, Brad, Brown, Christopher D., Smith, William C., Sidow, Arend
Format:	Artigo
Jezik:	Inglês
Izdano:	Cold Spring Harbor Laboratory Press 2004
Teme:	Letters
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC534669/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15545496/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gr.2964504
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