Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts.

Limitation of lifespan in replicative senescence is related to oxidative stress, which is probably both the cause and consequence of impaired mitochondrial respiratory function. The respiration of senescent human diploid fibroblasts was analysed by high-resolution respirometry. To rule out cell-cycl...

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Autores principales: Hutter, Eveline, Renner, Kathrin, Pfister, Gerald, Stöckl, Petra, Jansen-Dürr, Pidder, Gnaiger, Erich
Formato: Artigo
Lenguaje:Inglês
Publicado: 2004
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224220/
https://ncbi.nlm.nih.gov/pubmed/15018610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040095
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