Methionine restriction slows down senescence in human diploid fibroblasts

Methionine restriction (MetR) extends lifespan in animal models including rodents. Using human diploid fibroblasts (HDF), we report here that MetR significantly extends their replicative lifespan, thereby postponing cellular senescence. MetR significantly decreased activity of mitochondrial complex...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Kozieł, Rafał, Ruckenstuhl, Christoph, Albertini, Eva, Neuhaus, Michael, Netzberger, Christine, Bust, Maria, Madeo, Frank, Wiesner, Rudolf J, Jansen-Dürr, Pidder
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326930/
https://ncbi.nlm.nih.gov/pubmed/25273919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12266
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