Methionine restriction slows down senescence in human diploid fibroblasts

Methionine restriction (MetR) extends lifespan in animal models including rodents. Using human diploid fibroblasts (HDF), we report here that MetR significantly extends their replicative lifespan, thereby postponing cellular senescence. MetR significantly decreased activity of mitochondrial complex...

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Publicado en:Aging Cell
Autores principales: Kozieł, Rafał, Ruckenstuhl, Christoph, Albertini, Eva, Neuhaus, Michael, Netzberger, Christine, Bust, Maria, Madeo, Frank, Wiesner, Rudolf J, Jansen-Dürr, Pidder
Formato: Artigo
Lenguaje:Inglês
Publicado: BlackWell Publishing Ltd 2014
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4326930/
https://ncbi.nlm.nih.gov/pubmed/25273919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12266
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