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MEK Kinase 1, a Substrate for DEVD-Directed Caspases, Is Involved in Genotoxin-Induced Apoptosis

MEK kinase 1 (MEKK1) is a 196-kDa protein that, in response to genotoxic agents, was found to undergo phosphorylation-dependent activation. The expression of kinase-inactive MEKK1 inhibited genotoxin-induced apoptosis. Following activation by genotoxins, MEKK1 was cleaved in a caspase-dependent mann...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Widmann, Christian, Gerwins, Pär, Johnson, Nancy Lassignal, Jarpe, Matthew B., Johnson, Gary L.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 1998
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC121502/
https://ncbi.nlm.nih.gov/pubmed/9528810
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