Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.

Mitochondrial cytochrome c, which functions as an electron carrier in the respiratory chain, translocates to the cytosol in cells undergoing apoptosis, where it participates in the activation of DEVD-specific caspases. The apoptosis inhibitors Bcl-2 or Bcl-xL prevent the efflux of cytochrome c from...

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Hlavní autoři: Bossy-Wetzel, E, Newmeyer, D D, Green, D R
Médium: Artigo
Jazyk:Inglês
Vydáno: 1998
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170356/
https://ncbi.nlm.nih.gov/pubmed/9427739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.1.37
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