Activation of MEK Kinase 1 by the c-Abl Protein Tyrosine Kinase in Response to DNA Damage

The c-Abl protein tyrosine kinase is activated by certain DNA-damaging agents and regulates induction of the stress-activated c-Jun N-terminal protein kinase (SAPK). Here we show that nuclear c-Abl associates with MEK kinase 1 (MEKK-1), an upstream effector of the SEK1→SAPK pathway, in the response...

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Autores principales: Kharbanda, Surender, Pandey, Pramod, Yamauchi, Teruo, Kumar, Shailender, Kaneki, Masao, Kumar, Vijay, Bharti, Ajit, Yuan, Zhi-Min, Ghanem, Louis, Rana, Ajay, Weichselbaum, Ralph, Johnson, Gary, Kufe, Donald
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2000
Materias:
Cell Growth and Development
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC85948/
https://ncbi.nlm.nih.gov/pubmed/10866655
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