Role for Bcl-x(L) as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis

Cytochrome C is a mitochondrial protein that induces apoptosis when released into the cytosol or when added to cell-free extracts. Here we show that cells that overexpress the Bcl-2-related protein Bcl-x(L) fail to accumulate cytosolic cytochrome C or undergo apoptosis in response to genotoxic stres...

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Detaylı Bibliyografya
Asıl Yazarlar: Kharbanda, Surender, Pandey, Pramod, Schofield, Lesley, Israels, Sara, Roncinske, Richard, Yoshida, Kiyotsugu, Bharti, Ajit, Yuan, Zhi-Min, Saxena, Satya, Weichselbaum, Ralph, Nalin, Carlo, Kufe, Donald
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences of the USA 1997
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC21263/
https://ncbi.nlm.nih.gov/pubmed/9192670
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