Role for Bcl-x(L) as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis

Cytochrome C is a mitochondrial protein that induces apoptosis when released into the cytosol or when added to cell-free extracts. Here we show that cells that overexpress the Bcl-2-related protein Bcl-x(L) fail to accumulate cytosolic cytochrome C or undergo apoptosis in response to genotoxic stres...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kharbanda, Surender, Pandey, Pramod, Schofield, Lesley, Israels, Sara, Roncinske, Richard, Yoshida, Kiyotsugu, Bharti, Ajit, Yuan, Zhi-Min, Saxena, Satya, Weichselbaum, Ralph, Nalin, Carlo, Kufe, Donald
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21263/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9192670/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.13.6939
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