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Role for Bcl-x(L) as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis
Cytochrome C is a mitochondrial protein that induces apoptosis when released into the cytosol or when added to cell-free extracts. Here we show that cells that overexpress the Bcl-2-related protein Bcl-x(L) fail to accumulate cytosolic cytochrome C or undergo apoptosis in response to genotoxic stres...
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| Autors principals: | , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The National Academy of Sciences of the USA
1997
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC21263/ https://ncbi.nlm.nih.gov/pubmed/9192670 |
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