Caspase-mediated degradation of human 5-lipoxygenase in B lymphocytic cells

5-Lipoxygenase (5-LO) is a tightly regulated enzyme in the synthesis of bioactive lipids from arachidonic acid. Here, we demonstrate that 5-LO is regulated by caspases, which are signaling molecules that control critical biological processes by means of specific limited proteolysis. Cell splitting o...

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Autori principali: Werz, Oliver, Tretiakova, Irina, Michel, Angela, Ulke-Lemee, Annegret, Hörnig, Michael, Franke, Lutz, Schneider, Gisbert, Samuelsson, Bengt, Rådmark, Olof, Steinhilber, Dieter
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1201604/
https://ncbi.nlm.nih.gov/pubmed/16135563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505991102
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