Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis

5-Lipoxygenase (5LO) is a key enzyme in leukotriene (LT) biosynthesis. Two accessory proteins, coactosin-like protein (CLP) and 5-lipoxygenase–activating protein (FLAP), can support 5LO activity. To study the roles of CLP and FLAP, we knocked down these proteins in the human monocytic cell line Mono...

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Bibliographic Details
Main Authors: Basavarajappa, Devaraj, Wan, Min, Lukic, Ana, Steinhilber, Dieter, Samuelsson, Bengt, Rådmark, Olof
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128154/
https://ncbi.nlm.nih.gov/pubmed/25034252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410983111
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