Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A(4) production

Regulation of 5-lipoxygenase (5LO) activity is a key determinant for the biosynthesis of proinflammatory leukotrienes. Coactosin-like protein (CLP) is an F-actin-binding protein that can also bind 5LO. Here, we report that CLP can up-regulate and modulate 5LO activity [formation of 5(S)-hydroperoxy-...

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Detaylı Bibliyografya
Asıl Yazarlar: Rakonjac, Marija, Fischer, Lutz, Provost, Patrick, Werz, Oliver, Steinhilber, Dieter, Samuelsson, Bengt, Rådmark, Olof
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2006
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1559768/
https://ncbi.nlm.nih.gov/pubmed/16924104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605150103
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