Downstream E-Box–mediated Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene Transcription: Evidence for an Endogenous Mechanism of Transcriptional Repression

Regulation of the hTERT gene encoding the telomerase catalytic subunit plays an important role in human cell senescence, immortalization, and carcinogenesis. By examining the activity of various deleted or mutated hTERT promoter fragments, we show that an E-box element downstream of the transcriptio...

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Pubblicato in:	Mol Biol Cell
Autori principali:	Horikawa, Izumi, Cable, P. LouAnn, Mazur, Sharlyn J., Appella, Ettore, Afshari, Cynthia A., Barrett, J. Carl
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Cell Biology 2002
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC117927/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12181331/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E01-11-0107
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