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Downstream E-Box–mediated Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene Transcription: Evidence for an Endogenous Mechanism of Transcriptional Repression

Regulation of the hTERT gene encoding the telomerase catalytic subunit plays an important role in human cell senescence, immortalization, and carcinogenesis. By examining the activity of various deleted or mutated hTERT promoter fragments, we show that an E-box element downstream of the transcriptio...

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Main Authors: Horikawa, Izumi, Cable, P. LouAnn, Mazur, Sharlyn J., Appella, Ettore, Afshari, Cynthia A., Barrett, J. Carl
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Cell Biology 2002
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC117927/
https://ncbi.nlm.nih.gov/pubmed/12181331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E01-11-0107
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