SyrB2 in syringomycin E biosynthesis is a nonheme Fe(II) α-ketoglutarate- and O(2)-dependent halogenase

The nine-residue lipodepsipeptide syringomycin E, elaborated as a phytotoxin by Pseudomonas syringae pv. syringae B301D contains a 4-Cl-l-Thr-9 moiety where failure to chlorinate results in a 3-fold drop in biological activity. The proteins SyrB1 and SyrB2 encoded by the biosynthetic cluster are sho...

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Bibliographic Details
Main Authors: Vaillancourt, Frédéric H., Yin, Jun, Walsh, Christopher T.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1177402/
https://ncbi.nlm.nih.gov/pubmed/16002467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504412102
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