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Akt Maintains Cell Size and Survival by Increasing mTOR-dependent Nutrient Uptake

In multicellular organisms, constituent cells depend on extracellular signals for growth, proliferation, and survival. When cells are withdrawn from growth factors, they undergo apoptosis. Expression of constitutively active forms of the serine/threonine kinase Akt/PKB can prevent apoptosis upon gro...

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Detalhes bibliográficos
Main Authors: Edinger, Aimee L., Thompson, Craig B.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC117312/
https://ncbi.nlm.nih.gov/pubmed/12134068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.01-12-0584
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