Antiviral Effect of N-Butyldeoxynojirimycin against Bovine Viral Diarrhea Virus Correlates with Misfolding of E2 Envelope Proteins and Impairment of Their Association into E1-E2 Heterodimers

The iminosugar N-butyldeoxynojirimycin (NB-DNJ), an endoplasmic reticulum α-glucosidase inhibitor, has an antiviral effect against bovine viral diarrhea virus (BVDV). In this report, we investigate the molecular mechanism of this inhibition by studying the folding pathway of BVDV envelope glycoprote...

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Autors principals: Branza-Nichita, Norica, Durantel, David, Carrouée-Durantel, Sandra, Dwek, Raymond A., Zitzmann, Nicole
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC114844/
https://ncbi.nlm.nih.gov/pubmed/11264342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.8.3527-3536.2001
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