Antiviral Effect of N-Butyldeoxynojirimycin against Bovine Viral Diarrhea Virus Correlates with Misfolding of E2 Envelope Proteins and Impairment of Their Association into E1-E2 Heterodimers

The iminosugar N-butyldeoxynojirimycin (NB-DNJ), an endoplasmic reticulum α-glucosidase inhibitor, has an antiviral effect against bovine viral diarrhea virus (BVDV). In this report, we investigate the molecular mechanism of this inhibition by studying the folding pathway of BVDV envelope glycoprote...

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Bibliografische gegevens

Gepubliceerd in:	J Virol
Hoofdauteurs:	Branza-Nichita, Norica, Durantel, David, Carrouée-Durantel, Sandra, Dwek, Raymond A., Zitzmann, Nicole
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Microbiology (ASM) 2001
Onderwerpen:	Vaccines and Antiviral Agents
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114844/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11264342/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.8.3527-3536.2001
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