Antiviral Effect of N-Butyldeoxynojirimycin against Bovine Viral Diarrhea Virus Correlates with Misfolding of E2 Envelope Proteins and Impairment of Their Association into E1-E2 Heterodimers

The iminosugar N-butyldeoxynojirimycin (NB-DNJ), an endoplasmic reticulum α-glucosidase inhibitor, has an antiviral effect against bovine viral diarrhea virus (BVDV). In this report, we investigate the molecular mechanism of this inhibition by studying the folding pathway of BVDV envelope glycoprote...

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Pubblicato in:	J Virol
Autori principali:	Branza-Nichita, Norica, Durantel, David, Carrouée-Durantel, Sandra, Dwek, Raymond A., Zitzmann, Nicole
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Vaccines and Antiviral Agents
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC114844/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11264342/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.8.3527-3536.2001
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