Antiviral Effect of N-Butyldeoxynojirimycin against Bovine Viral Diarrhea Virus Correlates with Misfolding of E2 Envelope Proteins and Impairment of Their Association into E1-E2 Heterodimers

The iminosugar N-butyldeoxynojirimycin (NB-DNJ), an endoplasmic reticulum α-glucosidase inhibitor, has an antiviral effect against bovine viral diarrhea virus (BVDV). In this report, we investigate the molecular mechanism of this inhibition by studying the folding pathway of BVDV envelope glycoprote...

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Detalhes bibliográficos
Main Authors: Branza-Nichita, Norica, Durantel, David, Carrouée-Durantel, Sandra, Dwek, Raymond A., Zitzmann, Nicole
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114844/
https://ncbi.nlm.nih.gov/pubmed/11264342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.8.3527-3536.2001
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