Hybrid Vectors Based on Adeno-Associated Virus Serotypes 2 and 5 for Muscle-Directed Gene Transfer

Vectors based on hybrids consisting of adeno-associated virus types 2 (ITRs and Rep) and 5 (Cap) were evaluated for muscle-directed gene transfer (called AAV2/5). Evaluation in immune-competent mice revealed greater transduction efficacy with AAV2/5 than with AAV2 and no cross-neutralization between...

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Bibliographic Details
Main Authors: Hildinger, Markus, Auricchio, Alberto, Gao, Guangping, Wang, Lili, Chirmule, Narendra, Wilson, James M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Gene Therapy
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC114336/
https://ncbi.nlm.nih.gov/pubmed/11390622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.13.6199-6203.2001
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