Mitochondrial Reactive Oxygen Species Activation of p38 Mitogen-Activated Protein Kinase Is Required for Hypoxia Signaling

Mammalian cells have the ability to sense low oxygen levels (hypoxia). An adaptive response to hypoxia involves the induction of the transcription factor hypoxia-inducible factor 1 (HIF-1). The intracellular signaling pathways that regulate HIF-1 activation during hypoxia remain unknown. Here, we de...

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Bibliografiske detaljer
Main Authors: Emerling, Brooke M., Platanias, Leonidas C., Black, Emma, Nebreda, Angel R., Davis, Roger J., Chandel, Navdeep S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2005
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140591/
https://ncbi.nlm.nih.gov/pubmed/15923604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.12.4853-4862.2005
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