Mitochondrial Reactive Oxygen Species Activation of p38 Mitogen-Activated Protein Kinase Is Required for Hypoxia Signaling

Mammalian cells have the ability to sense low oxygen levels (hypoxia). An adaptive response to hypoxia involves the induction of the transcription factor hypoxia-inducible factor 1 (HIF-1). The intracellular signaling pathways that regulate HIF-1 activation during hypoxia remain unknown. Here, we de...

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Detalhes bibliográficos
Main Authors: Emerling, Brooke M., Platanias, Leonidas C., Black, Emma, Nebreda, Angel R., Davis, Roger J., Chandel, Navdeep S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140591/
https://ncbi.nlm.nih.gov/pubmed/15923604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.12.4853-4862.2005
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