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Reactive oxygen species (ROS) generation is stimulated by κ opioid receptor activation through phosphorylated c-Jun N-terminal kinase and inhibited by p38 mitogen-activated protein kinase (MAPK) activation
Activation of the mitogen-activated protein kinase (MAPK) c-Jun N-terminal kinase (JNK) by the G(i/o) protein–coupled κ opioid receptor (KOR), μ opioid, and D2 dopamine receptors stimulates peroxiredoxin 6 (PRDX6)-mediated production of reactive oxygen species (ROS). ROS production by KOR-inactivati...
Guardat en:
| Publicat a: | J Biol Chem |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6851317/ https://ncbi.nlm.nih.gov/pubmed/31575661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009592 |
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