Reactive oxygen species (ROS) generation is stimulated by κ opioid receptor activation through phosphorylated c-Jun N-terminal kinase and inhibited by p38 mitogen-activated protein kinase (MAPK) activation

Activation of the mitogen-activated protein kinase (MAPK) c-Jun N-terminal kinase (JNK) by the G(i/o) protein–coupled κ opioid receptor (KOR), μ opioid, and D2 dopamine receptors stimulates peroxiredoxin 6 (PRDX6)-mediated production of reactive oxygen species (ROS). ROS production by KOR-inactivati...

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Vydáno v:J Biol Chem
Hlavní autoři: Schattauer, Selena S., Bedini, Andrea, Summers, Floyd, Reilly-Treat, Aiden, Andrews, Mackenzie M., Land, Benjamin B., Chavkin, Charles
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6851317/
https://ncbi.nlm.nih.gov/pubmed/31575661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009592
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