TMC114, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor Active against Protease Inhibitor-Resistant Viruses, Including a Broad Range of Clinical Isolates

The purpose of this study was to characterize the antiviral activity, cytotoxicity, and mechanism of action of TMC114, a novel human immunodeficiency virus type 1 (HIV-1) protease inhibitor (PI). TMC114 exhibited potent anti-HIV activity with a 50% effective concentration (EC(50)) of 1 to 5 nM and a...

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Autores principales: De Meyer, Sandra, Azijn, Hilde, Surleraux, Dominique, Jochmans, Dirk, Tahri, Abdellah, Pauwels, Rudi, Wigerinck, Piet, de Béthune, Marie-Pierre
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140553/
https://ncbi.nlm.nih.gov/pubmed/15917527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.6.2314-2321.2005
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